Putative toxic metabolites

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WebJan 18, 2024 · The enclosed boxes highlight the putative toxic metabolites. Methanol is metabo-lized to formic acid, ethylene glycol to oxalic and glycolic acid, diethylene glycol to 2-hydroxyethoxyacetic acid and WebThe target organ of benzene toxicity, the hematopoietically active bone marrow, metabolizes benzene to a very limited extent. Phenol is metabolized in the marrow cells by a peroxidase-mediated pathway to hydroquinone and catechol, and ultimately to quinones, the putative toxic metabolites.

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WebIdentification of a toxic mechanism of the plasticizers, phtahlic acid esters, which are putative endocrine disrupters: time-dependent increase in quinolinic acid and its metabolites in rats fed di(2-ethylhexyl)phthalate WebJun 5, 2024 · Thousands of specialized, steroidal metabolites are found in a wide spectrum of plants. These include the steroidal glycoalkaloids (SGAs), produced primarily by most species of the genus Solanum, and metabolites belonging to the steroidal saponins class that are widespread throughout the plant kingdom.SGAs play a protective role in plants … extremity\u0027s 9b

Sulfur Conjugates as Putative Pneumotoxic Metabolites of the ...

WebDetection of sulphur-conjugated pyrrolic metabolites in blood and fresh or fixed liver tissue from rats given a variety of toxic pyrrolizidine alkaloids. Mattocks AR, Jukes R. Toxicol Lett, 63(1):47-55, 01 Oct 1992 Cited by: 9 articles PMID: 1412522 WebJan 1, 2002 · Tsutomu FUKUWATARI, Yuko SUZUKI, Etsuro SUGIMOTO, Katsumi SHIBATA, Identification of a Toxic Mechanism of the Plasticizers, Phtahlic Acid Esters, which are Putative Endocrine Disrupters: Time-dependent Increase in Quinolinic Acid and Its Metabolites in…, Bioscience, Biotechnology, and Biochemistry, Volume 66, Issue 12, 1 … WebJan 1, 2024 · Metabolite toxicity determines the pace of molecular evolution within microbial populations. PubMed. Lilja, Elin E; Johnson, David R. 2024-02-14. The production of toxic metabolit extremity\u0027s 9f

Short-chain dehydrogenase/reductase governs steroidal …

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WebApr 22, 2005 · Elucidating mechanisms of drug-induced toxicity. Daniel C. Liebler &. F. Peter Guengerich. Nature Reviews Drug Discovery 4 , 410–420 ( 2005) Cite this article. 6532 Accesses. 243 Citations. 15 ... WebNov 17, 2024 · Pathway analysis linked these changes to a putative toxic cholesterol pathway. Conclusion In conclusion, 4 bile acids may be useful to diagnose AD in plasma samples despite limitations in ... extremity\\u0027s 9oWebApr 10, 2024 · PR-toxin and Roquefortine C are the main toxic secondary metabolites produced by P. roqueforti, so they were treated separately ... Shantappa, S.; Feng, X.; Calvo, A.M. The putative C 2 H 2 transcription factor MtfA is a novel regulator of secondary metabolism and morphogenesis in Aspergillus nidulans. PLoS ONE 2013, 8, e74122 ... docusign envelope custom fields

"WebSimple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids Toxicon. 1989;27(5):561-7. doi: 10.1016/0041-0101(89)90117-7. ... (dehydro-alkaloids), which are probable primary toxic metabolites formed from these alkaloids in vivo. Preparations of dehydro-necines, including dehydroretronecine (DHR) are also described. " - Putative toxic metabolites

Putative toxic metabolites

Glutathione S-transferase: a versatile protein family

WebOct 1, 1992 · Rats were given single injections of hepatotoxic pyrrolizidine alkaloids and killed after 30 h. Sulphurbound pyrrolic metabolites from the alkaloids in samples of their blood or liver tissue were converted to extractable ethyl ethers of low molecular weight for detection and identification using TLC, HPLC or GC-MS. Liver samples were also … WebOct 18, 2024 · Several putative toxic metabolites of glucose have been identified. These include dihydroxyacetone phosphate (DHAP) and methylglyoxal that contribute to the generation of advanced glycation end products (AGEs) (Weimer et al., 2014).

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WebRebekah Jukes's 16 research works with 482 citations and 336 reads, including: P3B42. GSH-dependent biliary tract toxicity in the mouse caused by 9-oxo-10, 11-dehydroageraphorone (euptox) WebAug 28, 2012 · We and others have previously speculated that the multidrug antibiotic resistance (MDR) mechanisms in bacteria evolved in part as a mechanism to prevent the buildup of toxic metabolites , . In fact, we found that 2,3-dihydroxybenzoate, an intermediate in enterobactin biosynthesis, directly binds to and inactivates MarR, the key regulator of …

WebJun 1, 2024 · The enclosed boxes highlight the putative toxic metabolites. Methanol is metabolized to formic acid, ethylene glycol to oxalic and glycolic acid, diethylene glycol to 2-hydroxyethoxyacetic acid and glycolic acid, and propylene glycol to d -lactic and l -lactic acid. WebDOI: 10.1016/0041-0101(89)90117-7 Corpus ID: 45524101; Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids. @article{Mattocks1989SimplePF, title={Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids.}, author={A. Robin Mattocks and R Jukes and J. Brown}, journal={Toxicon : official journal …

WebA total of 87 human-specific metabolites were identified from the 17 drugs. We found that Meteor's positive predictions included 4 out of the 9 reported major metabolites (detected in excreta at a level of >10% of the administered p.o. dose) and 10 out of the 15 major phase II metabolites giving a total of 14 correctly predicted drug metabolite ... WebJan 1, 1989 · Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids. Toxicon 27, 561-567, 1989.-New procedures are described for converting unsaturated pyrrolizidine alkaloids to chemically reactive pyrrolic esters (dehydro-alkaloids), which are probable primary toxic metabolites formed from these alkaloids in vivo.

WebBakke, J. and Gustafsson, J.-A. (1984). Mercapturic acid pathway metabolites of xenobiotics: generation of potentially toxic metabolites during enterohepatic circulation. TIPS 5, 517–521. ... Simple procedures for preparing putative toxic metabolites of pyrrolizidine alkaloids. Toxicon 27, 561–567. CrossRef CAS PubMed Google Scholar

extremity\\u0027s 9hWebApr 13, 2024 · Phytochemical analysis showed that accumulation of individual metabolites in the line samples exceeded their levels in the native ... Moscow, Russia). Putative transgenic roots (HRs) were tested for the presence of the rolB (780 bp) (Sharan et al. 2024) and rolC (543 bp) (Thiruvengadam ... To study the toxicity of the drugs, ... extremity\u0027s 9hWebJan 18, 2024 · The enclosed boxes highlight the putative toxic metabolites. Methanol is metabolized to formic acid, ethylene glycol to oxalic and glycolic acid, ... extremity\u0027s 9iWebFeb 1, 2024 · The putative annotations obtained for these metabolites allowed us to generate hypothesis on their function. All sponge species investigated here appear to have metabolic interactions with their symbionts by providing them with 2-methylbutyryl-carnitine and carbohydrates, including scyllo-inositol, gluconic acid, ribose, fructose, and mannitol, … extremity\\u0027s 9kWebAug 3, 2024 · Overall, the model developed here provides a framework for inter-relating multiple sources of omics-level data and generating a list of putative metabolites associated with toxicant-induced organ ... extremity\u0027s 9gWebMar 24, 2024 · We next performed a BLAST search against protein sequences of the isolates to identify whether they can produce metabolites that are toxic for human health. No genes associated with toxic metabolite production were found in L. rhamnosus TK-F8B, B. animalis subsp. lactis TK-J6A, S. thermophilus TK-P3A, and L. paracasei TK-P4A (Fig. 2b, Table S10). extremity\u0027s 9oWebIf the total formation of the putative toxic metabolites is predictive of the toxicity of benzene, then the animal studies suggest that calculations of the risk associated with low dose exposures based on the results of animal studies conducted at high doses would underestimate the toxicity of benzene. The current report concerns only dosimetry. docusign esignature for box