Cisplatin mitochondria

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August undefined, 2024

WebJul 10, 2024 · Cisplatin is one of the worldwide anticancer drugs and, despite its toxicity and frequent recurrence of resistance phenomena, it still remains the only therapeutic … WebNational Center for Biotechnology Information

IJMS Free Full-Text Altered Retrograde Signaling Patterns in …

WebJul 1, 2024 · Background: Cisplatin resistance is one of the main causes of treatment failure and death in head and neck squamous cell carcinoma (HNSCC). A more comprehensive understanding of the cisplatin resistance mechanism and the development of effective treatment strategies are urgent. WebAug 6, 2015 · The foremost reason of cisplatin-related cytotoxicity has been correlated to the generation of mitochondrial reactive oxygen species (ROS) that influence multiple … bloom public school vasant kunj fees

Mitochondrial Involvement in Cisplatin Resistance - PubMed

WebNov 19, 2013 · Cisplatin is one of the most effective and widely used anticancer agents for the treatment of several types of tumors. The cytotoxic effect of cisplatin is … WebJan 9, 2024 · Cancer Drug 49 Times More Potent than Cisplatin ... business news WebKey results: We demonstrated that the prominent mitochondrial fragmentation occurred in experimental models of cisplatin-induced nephrotoxicity, which was coupled to radical oxygen species (ROS) overproduction, deterioration of mitochondrial function, release of apoptogenic factors and the consequent apoptosis. bloom punched justin beiber

VDAC1 as a target in cisplatin anti-tumor activity through …

The role of natural antioxidants in cisplatin-induced …

WebJul 5, 2024 · Mitophagy is an autophagic procedure that specifically clears damaged mitochondria and maintains its homeostasis. Emerging evidence indicates that mitophagy is involved in many physiological processes, including cellular homeostasis, cellular differentiation and nerve protection. WebA study in Chinese hamster ovary cells demonstrated that the proportion of adducts of cisplatin on mitochondrial DNA was four to six times higher compared to nuclear DNA by dissociation-enhanced lanthanide fluoroimmunoassay (DELFIA) and immunoelectron microscopy (Olivero et al., 1995; Jamieson and Lippard, 1999). bloomquilts.storeWebMitochondria do not have NER mechanisms for mtDNA. We demonstrate that cisplatin forms adducts with mtDNA in DRG neurons, and that this alters mtDNA replication and transcription. The resultant cisplatin-induced mitochondrial dysfunction may lead to a novel mechanism of cisplatin neurotoxicity. free download telegram for pc 64 bit

"WebThe cardiotoxic effect of chemotherapeutic agents as cisplatin has become a major issue recently. Interference with mitochondrial dynamics, biogenesis, redox status, and apoptosis are the most possible underlying mechanisms. Semaglutide is a human glucagon-like peptide-1 receptor agonist (GLP-1R), which is used primarily for the treatment of DM. " - Cisplatin mitochondria

Cisplatin mitochondria

IJMS Free Full-Text Altered Retrograde Signaling Patterns in …

Webmaintaining mitochondrial number and function is dem-onstrated by studies showing that the maturation of oo-cytes is severely impaired when mitochondrial activities are sub-optimal [26, 27]. Cisplatin is known to damage the DNA of oocytes, but the possibility that cisplatin also compromises oocyte survival and quality by damaging mitochondria ... WebCisplatin is a widely used antineoplastic agent. However, its major limitation is dose-dependent nephrotoxicity whose precise mechanism is poorly understood. Recent studies have suggested that mitochondrial dysfunction in tubular epithelium contributes to cisplatin-induced nephrotoxicity.

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WebOct 29, 2024 · Cisplatin induced mtDNA leakage into the cytosol-probably through BCL-2-like protein 4 (BAX) pores in the mitochondrial outer membrane-in tubules, with subsequent activation of the cGAS-STING...

WebMay 12, 2024 · Cis -diamminedichloroplatinum (II), or cisplatin, is one of the most commonly used chemotherapy agents in the treatment of various solid tumours such as ovarian, colorectal, prostate, lung, and... WebNational Center for Biotechnology Information

WebMay 7, 2024 · Meanwhile, cisplatin causes nuclear and mitochondrial DNA damage, which activates peroxisome proliferator-activated receptor-γ coactivator-1α and increases transcription factor A (TFAM) expression. TFAM transposition to the mitochondria leads to mitochondrial biosynthesis and activation, thereby increasing mitochondrial ROS and … WebDec 1, 2024 · Cisplatin is a chemotherapeutic drug that suppresses tumour's growth. • Cisplatin’s effectiveness is limited as it causes liver toxicity. • Various natural antioxidants protect against cisplatin-induced hepatotoxicity. • Hepatoprotective mechanisms are antioxidant, anti-inflammatory, and anti-apoptosis.

WebMore functional mitochondria in cisplatin-resistant compared with cisplatin-sensitive cells were associated to enzymatic changes affecting either the electron transport chain (SKOV-3/SKOV-3-R model) or mitochondrial coupling (COV-362/COV-362-R model).

WebNext, synergistic effect of cisplatin combined with ZD55-MnSOD on ovarian cancer cell SKOV-3 was quantified by combination index (CIN) analysis and expressed as CIN versus fraction affected in Figure 2B. These results showed that the combination of cisplatin and ZD55-MnSOD has an enhanced tumor killing effect. free download telegram for laptopWebJul 6, 2016 · Cisplatin (cis diamminedichloroplatinum II, cDDP) is one of the most effective cancer chemotherapeutic agents and is used in the treatment of many types of human malignancies. However, inherent tumour resistance is a major barrier to effective cisplatin therapy. So far, the mechanism of cDDP resistance has not been well defined. bloomqualityWebJun 30, 2024 · The novel aspect of our work suggested that cisplatin not only induces mitochondrial oxidative damage by attacking DNA and proteins in cancer cells, but also restrain mitochondria self-renewal by inhibiting mitochondrial fission and mitophagy, which lead to damaged mitochondrial accumulation. free download telegram x for pcWebNov 7, 2024 · Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells. Patients with high-grade serous ovarian … bloom public school fee structureWebThe cellular uptake of cisplatin and its targets. Reprinted with permission. 1 As seen in Figure 1, once inside the cell, cisplatin has a number of possible targets: DNA; RNA; sulfur-containing enzymes such as metallothionein and glutathione; and mitochondria. free download telegram webWeb2 days ago · Complex 37 and, above all, 38, were the most effective, but the latter led to higher activated Pt content inside the cells (probably because of its greater reduction rate), as well as inside the mitochondria, compared with complex 37 and cisplatin. To explore the mitochondrial effect caused by complexes 37 and 38, the level of mitochondria ... free download telegram for windows 10WebApr 23, 2024 · Cisplatin / toxicity Drugs, Chinese Herbal / therapeutic use* Humans Hyperalgesia / chemically induced Hyperalgesia / drug therapy Membrane Potential, Mitochondrial / drug effects Mice Neurotoxicity Syndromes Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Drugs, Chinese Herbal free download telegram premium apk